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LILRB4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8NHJ6 |
|---|---|
| Clone Names | 100318025 |
| Gene ID | 11006 |
|---|---|
| Other Names | Leukocyte immunoglobulin-like receptor subfamily B member 4, CD85 antigen-like family member K, Immunoglobulin-like transcript 3, ILT-3, Leukocyte immunoglobulin-like receptor 5, LIR-5, Monocyte inhibitory receptor HM18, CD85k, LILRB4, ILT3, LIR5 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | LILRB4 |
|---|---|
| Synonyms | ILT3, LIR5 |
| Function | Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462). Receptor for FN1 (PubMed:34089617). Receptor for apolipoprotein APOE (PubMed:30333625). Receptor for ALCAM/CD166 (PubMed:29263213). Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699). Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736). This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617). Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213). Induces up- regulation of CD86 on dendritic cells (PubMed:19860908). Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462). |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Note=Ligand binding leads to internalization and translocation to an antigen-processing compartment |
| Tissue Location | Detected on monocytes, macrophages, dendritic cells, natural killer cells and B-cells (at protein level). Expressed in the lung. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Background
This gene is a member of the leukocyte immunoglobulin-likereceptor (LIR) family, which is found in a gene cluster atchromosomal region 19q13.4. The encoded protein belongs to thesubfamily B class of LIR receptors which contain two or fourextracellular immunoglobulin domains, a transmembrane domain, andtwo to four cytoplasmic immunoreceptor tyrosine-based inhibitorymotifs (ITIMs). The receptor is expressed on immune cells where itbinds to MHC class I molecules on antigen-presenting cells andtransduces a negative signal that inhibits stimulation of an immuneresponse. The receptor can also function in antigen capture andpresentation. It is thought to control inflammatory responses andcytotoxicity to help focus the immune response and limitautoreactivity. Multiple transcript variants encoding differentisoforms have been found for this gene.
References
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Lu, H.K., et al. J. Biol. Chem. 284(50):34839-34848(2009)Jones, D.C., et al. Eur. J. Immunol. 39(11):3195-3206(2009)Brenk, M., et al. J. Immunol. 183(1):145-154(2009)Brown, D.P., et al. BMC Immunol. 10, 56 (2009) :
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