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SENP1 Antibody (C-term) Blocking Peptide

Synthetic peptide

     
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Product Information
Primary Accession Q9P0U3
Clone Names 2012311
Peptide ID 2012311
Additional Information
Gene ID 29843
Other Names Sentrin-specific protease 1, Sentrin/SUMO-specific protease SENP1, SENP1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1231a was selected from the C-term region of human SENP1. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SENP1
Function Protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. Deconjugates SUMO1 from HIPK2. Deconjugates SUMO1 from HDAC1 and BHLHE40/DEC1, which decreases its transcriptional repression activity. Deconjugates SUMO1 from CLOCK, which decreases its transcriptional activation activity. Deconjugates SUMO2 from MTA1.
Cellular Location Nucleus. Cytoplasm. Note=Shuttles between cytoplasm and nucleus
Tissue Location Highly expressed in testis. Expressed at lower levels in thymus, pancreas, spleen, liver, ovary and small intestine.
Research Areas
Citations (0)

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Background

SENP1 is a protease that catalyzes two essential functions in the SUMO pathway: processing of full-length SUMO1, SUMO2 and SUMO3 to their mature forms and deconjugation of SUMO1, SUMO2 and SUMO3 from targeted proteins. SENP deconjugates SUMO1 from HIPK2 and from HDAC1, which decreases the transcriptional repression activity of the latter.

References

Gong, L., et al., J. Biol. Chem. 275(5):3355-3359 (2000).Bailey, D., et al., J. Gen. Virol. 83 (Pt 12), 2951-2964 (2002).

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$ 80.00
Cat# BP1231a
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