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DVL1 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession O14640
Clone Names 101008125
Peptide ID 101008125
Additional Information
Gene ID 1855
Other Names Segment polarity protein dishevelled homolog DVL-1, Dishevelled-1, DSH homolog 1, DVL1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name DVL1
Function Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes. Required for LEF1 activation upon WNT1 and WNT3A signaling. DVL1 and PAK1 form a ternary complex with MUSK which is important for MUSK-dependent regulation of AChR clustering during the formation of the neuromuscular junction (NMJ).
Cellular Location Cell membrane; Peripheral membrane protein; Cytoplasmic side Cytoplasm, cytosol. Cytoplasmic vesicle. Note=Localizes at the cell membrane upon interaction with frizzled family members.
Research Areas
Citations (0)

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DVL1, the human homolog of the Drosophila dishevelled gene(dsh) encodes a cytoplasmic phosphoprotein that regulates cellproliferation, acting as a transducer molecule for developmentalprocesses, including segmentation and neuroblast specification.DVL1 is a candidate gene for neuroblastomatous transformation. TheSchwartz-Jampel syndrome and Charcot-Marie-Tooth disease type 2Ahave been mapped to the same region as DVL1. The phenotypes ofthese diseases may be consistent with defects which might beexpected from aberrant expression of a DVL gene during development.


Metcalfe, C., et al. J. Cell. Sci. 123 (PT 9), 1588-1599 (2010) :Hu, T., et al. J. Biol. Chem. 285(18):13561-13568(2010)Varelas, X., et al. Dev. Cell 18(4):579-591(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Guo, J., et al. PLoS ONE 4 (11), E7982 (2009) :

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$ 80.00
Cat# BP12326c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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