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Synthetic peptide
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- BACKGROUND
| Primary Accession | Q9BTZ2 |
|---|---|
| Clone Names | 101008017 |
| Peptide ID | 101008017 |
| Gene ID | 10901 |
|---|---|
| Other Names | Dehydrogenase/reductase SDR family member 4, NADPH-dependent carbonyl reductase/NADP-retinol dehydrogenase, CR, PHCR, NADPH-dependent retinol dehydrogenase/reductase, NRDR, humNRDR, Peroxisomal short-chain alcohol dehydrogenase, PSCD, SCAD-SRL, Short-chain dehydrogenase/reductase family member 4, DHRS4 |
| Format | Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | DHRS4 |
|---|---|
| Synonyms | SDR25C2 |
| Function | Reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co- factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity). |
| Cellular Location | Peroxisome. Note=Isoform 1 is peroxisomal, while isoform 4 is not |
| Tissue Location | Isoform 1 is predominantly expressed in normal cervix (at protein level). Isoform 4 is expressed in some neoplastic cervical tissues, but not in normal cervix (at protein level). Isoform 5 and isoform 6 are expressed in a few neoplastic cervical tissues |
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Provided below are standard protocols that you may find useful for product applications.
Background
DHRS4 reduces all-trans-retinal and 9-cis retinal. Can also catalyze the oxidation of all-trans-retinol with NADP as co-factor, but with much lower efficiency. Reduces alkyl phenyl ketones and alpha-dicarbonyl compounds with aromatic rings, such as pyrimidine-4-aldehyde, 3-benzoylpyridine, 4-benzoylpyridine, menadione and 4-hexanoylpyridine. Has no activity towards aliphatic aldehydes and ketones (By similarity).
References
Su, Z.J., et al. BMC Mol. Biol. 11, 43 (2010) :Persson, B., et al. Chem. Biol. Interact. 178 (1-3), 94-98 (2009) :Zhang, Q., et al. Biosci. Rep. 29(1):47-56(2009)Matsunaga, T., et al. Arch. Biochem. Biophys. 477(2):339-347(2008)Ferreira, M.A., et al. Nat. Genet. 40(9):1056-1058(2008)
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