|Other Names||Cytochrome c oxidase subunit 7A-related protein, mitochondrial, COX7a-related protein, Cytochrome c oxidase subunit VIIa-related protein, EB1, COX7A2L, COX7AR, COX7RP|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity).|
|Cellular Location||Mitochondrion inner membrane.|
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Provided below are standard protocols that you may find useful for product applications.
Cytochrome c oxidase (COX), the terminal component of themitochondrial respiratory chain, catalyzes the electron transferfrom reduced cytochrome c to oxygen. This component is aheteromeric complex consisting of 3 catalytic subunits encoded bymitochondrial genes and multiple structural subunits encoded bynuclear genes. The mitochondrially-encoded subunits function inelectron transfer, and the nuclear-encoded subunits may function inthe regulation and assembly of the complex. This nuclear geneencodes a protein similar to polypeptides 1 and 2 of subunit VIIain the C-terminal region, and also highly similar to the mouseSig81 protein sequence. This gene is expressed in all tissues, andupregulated in a breast cancer cell line after estrogen treatment.It is possible that this gene represents a regulatory subunit ofCOX and mediates the higher level of energy production in targetcells by estrogen.
Fornuskova, D., et al. Biochem. J. 428(3):363-374(2010)Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)Schmidt, T.R., et al. J. Mol. Evol. 57(2):222-228(2003)Lee, N., et al. Am. J. Hum. Genet. 68(2):397-409(2001)
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