COX7A2L Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | O14548 |
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Clone Names | 101008299 |
Gene ID | 9167 |
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Other Names | Cytochrome c oxidase subunit 7A-related protein, mitochondrial, COX7a-related protein, Cytochrome c oxidase subunit VIIa-related protein, EB1, COX7A2L, COX7AR, COX7RP |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | COX7A2L |
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Synonyms | COX7AR, COX7RP |
Function | Involved in the regulation of oxidative phosphorylation and energy metabolism (By similarity). Necessary for the assembly of mitochondrial respiratory supercomplex (By similarity). |
Cellular Location | Mitochondrion inner membrane. |
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Provided below are standard protocols that you may find useful for product applications.
Background
Cytochrome c oxidase (COX), the terminal component of themitochondrial respiratory chain, catalyzes the electron transferfrom reduced cytochrome c to oxygen. This component is aheteromeric complex consisting of 3 catalytic subunits encoded bymitochondrial genes and multiple structural subunits encoded bynuclear genes. The mitochondrially-encoded subunits function inelectron transfer, and the nuclear-encoded subunits may function inthe regulation and assembly of the complex. This nuclear geneencodes a protein similar to polypeptides 1 and 2 of subunit VIIain the C-terminal region, and also highly similar to the mouseSig81 protein sequence. This gene is expressed in all tissues, andupregulated in a breast cancer cell line after estrogen treatment.It is possible that this gene represents a regulatory subunit ofCOX and mediates the higher level of energy production in targetcells by estrogen.
References
Fornuskova, D., et al. Biochem. J. 428(3):363-374(2010)Wheeler, H.E., et al. PLoS Genet. 5 (10), E1000685 (2009) :Wang, L., et al. Cancer Epidemiol. Biomarkers Prev. 17(12):3558-3566(2008)Schmidt, T.R., et al. J. Mol. Evol. 57(2):222-228(2003)Lee, N., et al. Am. J. Hum. Genet. 68(2):397-409(2001)
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