|Other Names||Translin, 31--, Component 3 of promoter of RISC, C3PO, TSN|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|
|Cellular Location||Cytoplasm. Nucleus|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a DNA-binding protein which specificallyrecognizes conserved target sequences at the breakpoint junction ofchromosomal translocations. Translin polypeptides form a multimericstructure that is responsible for its DNA-binding activity.Recombination-associated motifs and translin-binding sites arepresent at recombination hotspots and may serve as indicators ofbreakpoints in genes which are fused by translocations. Thesebinding activities may play a crucial role in chromosomaltranslocation in lymphoid neoplasms.
Chiaruttini, C., et al. Proc. Natl. Acad. Sci. U.S.A. 106(38):16481-16486(2009)Lasky-Su, J., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 147B (8), 1345-1354 (2008) :Sengupta, K., et al. Biochemistry 45(3):861-870(2006)Kaluzhny, D., et al. J. Biomol. Struct. Dyn. 23(3):257-265(2005)Gupta, G.D., et al. FEBS Lett. 579(14):3141-3146(2005)
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