|Other Names||Phosphatidylinositol N-acetylglucosaminyltransferase subunit A, GlcNAc-PI synthesis protein, Phosphatidylinositol-glycan biosynthesis class A protein, PIG-A, PIGA|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Necessary for the synthesis of N-acetylglucosaminyl- phosphatidylinositol, the very early intermediate in GPI-anchor biosynthesis.|
|Cellular Location||Endoplasmic reticulum membrane; Single-pass membrane protein|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein required for synthesis ofN-acetylglucosaminyl phosphatidylinositol (GlcNAc-PI), the firstintermediate in the biosynthetic pathway of GPI anchor. The GPIanchor is a glycolipid found on many blood cells and which servesto anchor proteins to the cell surface. Paroxysmal nocturnalhemoglobinuria, an acquired hematologic disorder, has been shown toresult from mutations in this gene. Alternate splice variants havebeen characterized. A related pseudogene is located on chromosome12.
Borowitz, M.J., et al. Cytometry B Clin Cytom 78(4):211-230(2010)Peruzzi, B., et al. Mutat. Res. 705(1):3-10(2010)Araten, D.J., et al. Mutat. Res. 686 (1-2), 1-8 (2010) :Iida, Y., et al. Blood 83(11):3126-3131(1994)Ware, R.E., et al. Blood 83(9):2418-2422(1994)
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