|Other Names||Protein Wnt-9a, Protein Wnt-14, WNT9A, WNT14|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt/beta- catenin signaling pathway. Required for normal timing of IHH expression during embryonic bone development, normal chondrocyte maturation and for normal bone mineralization during embryonic bone development. Plays a redundant role in maintaining joint integrity.|
|Cellular Location||Secreted, extracellular space, extracellular matrix. Secreted|
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The WNT gene family consists of structurally related genesthat encode secreted signaling proteins. These proteins have beenimplicated in oncogenesis and in several developmental processes,including regulation of cell fate and patterning duringembryogenesis. This gene is a member of the WNT gene family. It isexpressed in gastric cancer cell lines. The protein encoded by thisgene shows 75% amino acid identity to chicken Wnt14, which has beenshown to play a central role in initiating synovial joint formationin the chick limb. This gene is clustered with another familymember, WNT3A, in the chromosome 1q42 region.
Lee, D.Y., et al. Menopause 17(5):1064-1070(2010)Memarian, A., et al. Leuk. Lymphoma 50(12):2061-2070(2009)Yerges, L.M., et al. J. Bone Miner. Res. 24(12):2039-2049(2009)Xiang, Y., et al. Mol. Biol. Rep. 35(2):73-79(2008)Bhattacharyya, S., et al. Dig. Dis. Sci. 52(10):2766-2774(2007)
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