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I23O2 Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q6ZQW0
Clone Names 91208196
Peptide ID 91208196
Additional Information
Gene ID 169355
Other Names Indoleamine 2, 3-dioxygenase 2, IDO-2, 11311-, Indoleamine 2, 3-dioxygenase-like protein 1, Indoleamine-pyrrole 2, 3-dioxygenase-like protein 1, IDO2, INDOL1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name IDO2
Synonyms INDOL1
Function Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174). Involved in immune regulation. May not play a significant role in tryptophan-related tumoral resistance (PubMed:25691885).
Tissue Location Detected in liver, small intestine, spleen, placenta, thymus, lung, brain, kidney, and colon (PubMed:17671174). Also expressed at low level in testis and thyroid. Not expressed in the majority of human tumor samples (>99%) (PubMed:25691885).
Research Areas
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Background

Along with the enzymes encoded by the INDO (MIM 147435)and TDO2 (MIM 191070) genes, the enzyme encoded by the INDOL1 genemetabolizes tryptophan in the kynurenine pathway (Ball et al., 2007[PubMed 17499941]).

References

Cetindere, T., et al. Cell. Signal. 22(2):197-211(2010)Huttunen, R., et al. Shock 33(2):149-154(2010)Witkiewicz, A.K., et al. J. Am. Coll. Surg. 208(5):781-787(2009)Metz, R., et al. Cancer Res. 67(15):7082-7087(2007)Ball, H.J., et al. Gene 396(1):203-213(2007)

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$ 80.00
Cat# BP12406b
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