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TCF7L2 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q9NQB0
Clone Names 80924005
Peptide ID 80924005
Additional Information
Gene ID 6934
Other Names Transcription factor 7-like 2, HMG box transcription factor 4, T-cell-specific transcription factor 4, T-cell factor 4, TCF-4, hTCF-4, TCF7L2, TCF4
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TCF7L2
Synonyms TCF4
Function Participates in the Wnt signaling pathway and modulates MYC expression by binding to its promoter in a sequence-specific manner. Acts as repressor in the absence of CTNNB1, and as activator in its presence. Activates transcription from promoters with several copies of the Tcf motif 5'-CCTTTGATC-3' in the presence of CTNNB1. TLE1, TLE2, TLE3 and TLE4 repress transactivation mediated by TCF7L2/TCF4 and CTNNB1. Expression of dominant-negative mutants results in cell-cycle arrest in G1. Necessary for the maintenance of the epithelial stem-cell compartment of the small intestine.
Cellular Location Nucleus, PML body. Note=Diffuse pattern. Colocalizes with SUMO1 and PIAS4 in a subset of PML (promyelocytic leukemia) nuclear bodies
Tissue Location Detected in epithelium from small intestine, with the highest expression at the top of the crypts and a gradient of expression from crypt to villus. Detected in colon epithelium and colon cancer, and in epithelium from mammary gland and carcinomas derived therefrom.
Research Areas
Citations (0)

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This gene encodes a high mobility group (HMG)box-containing transcription factor that plays a key role in theWnt signaling pathway. The protein has been implicated in bloodglucose homeostasis. Genetic variants of this gene are associatedwith increased risk of type 2 diabetes. Several transcript variantsencoding multiple different isoforms have been found for this gene.


Hansson, O., et al. Curr. Diab. Rep. 10(6):444-451(2010)Heni, M., et al. Diabetes (2010) In press :Potapov, V.A., et al. Genetika 46(8):1123-1131(2010)Kucharska-Newton, A.M., et al. J Obes 2010 (2010) :Zabaneh, D., et al. PLoS ONE 5 (8), E11961 (2010) :

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$ 80.00
Cat# BP12416a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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