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EYA1 Antibody (N-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q99502
Clone Names 100311215
Peptide ID 100311215
Additional Information
Gene ID 2138
Other Names Eyes absent homolog 1, EYA1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name EYA1
Function Functions both as protein phosphatase and as transcriptional coactivator for SIX1, and probably also for SIX2, SIX4 and SIX5. Tyrosine phosphatase that dephosphorylates 'Tyr- 142' of histone H2AX (H2AXY142ph) and promotes efficient DNA repair via the recruitment of DNA repair complexes containing MDC1. 'Tyr-142' phosphorylation of histone H2AX plays a central role in DNA repair and acts as a mark that distinguishes between apoptotic and repair responses to genotoxic stress. Its function as histone phosphatase may contribute to its function in transcription regulation during organogenesis. Has also phosphatase activity with proteins phosphorylated on Ser and Thr residues (in vitro). Required for normal embryonic development of the craniofacial and trunk skeleton, kidneys and ears. Together with SIX1, it plays an important role in hypaxial muscle development; in this it is functionally redundant with EYA2.
Cellular Location Cytoplasm. Nucleus. Note=Localizes at sites of DNA damage at double-strand breaks (DSBs)
Tissue Location In the embryo, highly expressed in kidney with lower levels in brain. Weakly expressed in lung. In the adult, highly expressed in heart and skeletal muscle. Weakly expressed in brain and liver. No expression in eye or kidney
Research Areas
Citations (0)

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This gene encodes a member of the eyes absent (EYA) familyof proteins. The encoded protein may play a role in the developingkidney, branchial arches, eye, and ear. Mutations of this gene havebeen associated with branchiootorenal dysplasia syndrome,branchiootic syndrome, and sporadic cases of congenital cataractsand ocular anterior segment anomalies. A similar protein in micecan act as a transcriptional activator. Four transcript variantsencoding three distinct isoforms have been identified for thisgene.


Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Lin, L., et al. Zhonghua Zheng Xing Wai Ke Za Zhi 25(6):436-439(2009)Drake, K.M., et al. Clin. Cancer Res. 15(19):5985-5992(2009)Patrick, A.N., et al. J. Biol. Chem. 284(31):20781-20790(2009)Lee, J.D., et al. Ann. Clin. Lab. Sci. 39(3):303-306(2009)

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$ 80.00
Cat# BP12446a
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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