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PION Antibody (C-term) Blocking peptide

Synthetic peptide

Product Information
Primary Accession A4D1B5
Clone Names 91218220
Peptide ID 91218220
Additional Information
Gene ID 54103
Other Names Gamma-secretase-activating protein, GSAP, Protein pigeon homolog, Gamma-secretase-activating protein 16 kDa C-terminal form, GSAP-16K, GSAP, PION
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms PION
Function Regulator of gamma-secretase activity, which specifically activates the production of beta-amyloid protein (beta-amyloid protein 40 and beta-amyloid protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The gamma-secretase complex is an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors and APP (beta-amyloid precursor protein). Specifically promotes the gamma-cleavage of APP CTF-alpha (also named APP-CTF) by the gamma-secretase complex to generate beta- amyloid, while it reduces the epsilon-cleavage of APP CTF-alpha, leading to a low production of AICD.
Cellular Location Golgi apparatus, trans-Golgi network
Tissue Location Widely expressed.
Research Areas
Citations (0)

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Accumulation of neurotoxic amyloid-beta is a majorhallmark of Alzheimer disease (AD; MIM 104300). Formation ofamyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM104311), a protease with numerous substrates. PION, or GSAP,selectively increases amyloid-beta production through a mechanisminvolving its interaction with both gamma-secretase and itssubstrate, the amyloid-beta precursor protein (APP; MIM 104760)C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed20811458]).


He, G., et al. Nature 467(7311):95-98(2010)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)

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$ 80.00
Cat# BP12480b
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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