|Other Names||T-cell leukemia homeobox protein 1, Homeobox protein Hox-11, Proto-oncogene TCL-3, T-cell leukemia/lymphoma protein 3, TLX1, HOX11, TCL3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'.|
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This gene encodes a nuclear transcription factor thatbelongs to the NK-linked or NK-like (NKL) subfamily of homeoboxgenes. The encoded protein is required for normal development ofthe spleen during embryogenesis. This protein is also involved inspecification of neuronal cell fates. Ectopic expression of thisgene due to chromosomal translocations is associated with certainT-cell acute lymphoblastic leukemias. Alternate splicing results inmultiple transcript variants.
De Keersmaecker, K., et al. Nat. Med. 16(11):1321-1327(2010)Milech, N., et al. Leuk. Res. 34(3):358-363(2010)Zweier-Renn, L.A., et al. Genes Chromosomes Cancer 49(2):119-131(2010)Riz, I., et al. Mol. Cancer 9, 181 (2010) :Dear, T.N., et al. Proc. Natl. Acad. Sci. U.S.A. 90(10):4431-4435(1993)
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