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TLX1 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P31314 |
|---|---|
| Clone Names | 100318018 |
| Gene ID | 3195 |
|---|---|
| Other Names | T-cell leukemia homeobox protein 1, Homeobox protein Hox-11, Proto-oncogene TCL-3, T-cell leukemia/lymphoma protein 3, TLX1, HOX11, TCL3 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | TLX1 |
|---|---|
| Synonyms | HOX11, TCL3 |
| Function | Controls the genesis of the spleen. Binds to the DNA sequence 5'-GGCGGTAAGTGG-3'. |
| Cellular Location | Nucleus. |
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a nuclear transcription factor thatbelongs to the NK-linked or NK-like (NKL) subfamily of homeoboxgenes. The encoded protein is required for normal development ofthe spleen during embryogenesis. This protein is also involved inspecification of neuronal cell fates. Ectopic expression of thisgene due to chromosomal translocations is associated with certainT-cell acute lymphoblastic leukemias. Alternate splicing results inmultiple transcript variants.
References
De Keersmaecker, K., et al. Nat. Med. 16(11):1321-1327(2010)Milech, N., et al. Leuk. Res. 34(3):358-363(2010)Zweier-Renn, L.A., et al. Genes Chromosomes Cancer 49(2):119-131(2010)Riz, I., et al. Mol. Cancer 9, 181 (2010) :Dear, T.N., et al. Proc. Natl. Acad. Sci. U.S.A. 90(10):4431-4435(1993)
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