|Other Names||Interferon-induced guanylate-binding protein 1, GTP-binding protein 1, GBP-1, HuGBP-1, Guanine nucleotide-binding protein 1, GBP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Hydrolyzes GTP to GMP in 2 consecutive cleavage reactions. Exhibits antiviral activity against influenza virus. Promote oxidative killing and deliver antimicrobial peptides to autophagolysosomes, providing broad host protection against different pathogen classes.|
|Cellular Location||Cytoplasm. Golgi apparatus membrane; Lipid-anchor; Cytoplasmic side. Cell membrane. Secreted. Note=Secreted from endothelial cells in the cerebrospinal fluid, upon bacterial challenge and independently of IFNG induction. Golgi membrane localization requires isoprenylation and the presence of another IFNG-induced factor|
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Provided below are standard protocols that you may find useful for product applications.
Guanylate binding protein expression is induced byinterferon. Guanylate binding proteins are characterized by theirability to specifically bind guanine nucleotides (GMP, GDP, andGTP) and are distinguished from the GTP-binding proteins by thepresence of 2 binding motifs rather than 3.
Vopel, T., et al. J. Mol. Biol. 400(1):63-70(2010)Mirpuri, J., et al. J. Immunol. 184(12):7186-7195(2010)Lipnik, K., et al. Mol. Med. 16 (5-6), 177-187 (2010) :Davila, S., et al. Genes Immun. 11(3):232-238(2010)O'Doherty, C., et al. Pharmacogenomics 10(7):1177-1186(2009)
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