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CCT8 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P50990 |
|---|---|
| Clone Names | 100318185 |
| Gene ID | 10694 |
|---|---|
| Other Names | T-complex protein 1 subunit theta, TCP-1-theta, CCT-theta, Renal carcinoma antigen NY-REN-15, CCT8, C21orf112, CCTQ, KIAA0002 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CCT8 |
|---|---|
| Synonyms | C21orf112, CCTQ, KIAA0002 |
| Function | Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis (PubMed:25467444). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638). The TRiC complex plays a role in the folding of actin and tubulin (Probable). |
| Cellular Location | Cytoplasm. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Cytoplasm, cytoskeleton, cilium basal body {ECO:0000250|UniProtKB:P42932} |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
Molecular chaperone; CCT8 assists the folding of proteins upon ATP hydrolysis. As part of the BBS/CCT complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. Known to play a role, in vitro, in the folding of actin and tubulin.
References
Mukherjee, K., et al. BMC Evol. Biol. 10, 64 (2010) :Zebol, J.R., et al. Int. J. Biochem. Cell Biol. 41(4):822-827(2009)Kim, S.C., et al. Mol. Cell 23(4):607-618(2006)Hu, Y.H., et al. BMC Genomics 7, 155 (2006) :Wang, L., et al. J. Mol. Med. 83(10):812-821(2005)
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