|Other Names||Peripherin-2, Retinal degeneration slow protein, Tetraspanin-22, Tspan-22, PRPH2, PRPH, RDS, TSPAN22|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||PRPH, RDS, TSPAN22|
|Function||May function as an adhesion molecule involved in stabilization and compaction of outer segment disks or in the maintenance of the curvature of the rim. It is essential for disk morphogenesis.|
|Cellular Location||Membrane; Multi-pass membrane protein.|
|Tissue Location||Retina (photoreceptor). In rim region of ROS (rod outer segment) disks|
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The protein encoded by this gene is a member of thetransmembrane 4 superfamily, also known as the tetraspanin family.Most of these members are cell-surface proteins that arecharacterized by the presence of four hydrophobic domains. Theproteins mediate signal transduction events that play a role in theregulation of cell development, activation, growth and motility.This encoded protein is a cell surface glycoprotein found in theouter segment of both rod and cone photoreceptor cells. It mayfunction as an adhesion molecule involved in stabilization andcompaction of outer segment disks or in the maintenance of thecurvature of the rim. This protein is essential for diskmorphogenesis. Defects in this gene are associated with bothcentral and peripheral retinal degenerations. Some of the variousphenotypically different disorders are autosomal dominant retinitispigmentosa, progressive macular degeneration, macular dystrophy andretinitis pigmentosa digenic.
Poloschek, C.M., et al. Invest. Ophthalmol. Vis. Sci. 51(8):4253-4265(2010)Vos, W.L., et al. Eur. Biophys. J. 39(4):679-688(2010)Matias-Florentino, M., et al. Curr. Eye Res. 34(12):1050-1056(2009)Lim, K.P., et al. Arch. Ophthalmol. 127(6):784-790(2009)Anand, S., et al. Retina (Philadelphia, Pa.) 29(5):682-688(2009)
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