|Other Names||Ficolin-3, Collagen/fibrinogen domain-containing lectin 3 p35, Collagen/fibrinogen domain-containing protein 3, Hakata antigen, FCN3, FCNH, HAKA1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May function in innate immunity through activation of the lectin complement pathway. Calcium-dependent and GlcNAc- binding lectin. Has affinity with GalNAc, GlcNAc, D-fucose, as mono/oligosaccharide and lipopolysaccharides from S.typhimurium and S.minnesota.|
|Cellular Location||Secreted. Note=Found in blood plasma, bronchus, alveolus and bile duct|
|Tissue Location||Liver and lung. In liver it is produced by bile duct epithelial cells and hepatocytes. In lung it is produced by both ciliated bronchial epithelial cells and type II alveolar epithelial cells.|
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Ficolins are a group of proteins which consist of acollagen-like domain and a fibrinogen-like domain. In human serum,there are two types of ficolins, both of which have lectinactivity. The protein encoded by this gene is a thermolabilebeta-2-macroglycoprotein found in all human serum and is a memberof the ficolin/opsonin p35 lectin family. The protein, which wasinitially identified based on its reactivity with sera frompatients with systemic lupus erythematosus, has been shown to havea calcium-independent lectin activity. The protein can activate thecomplement pathway in association with MASPs and sMAP, therebyaiding in host defense through the activation of the lectinpathway. Alternative splicing occurs at this locus and twovariants, each encoding a distinct isoform, have been identified.
Davila, S., et al. Genes Immun. 11(3):232-238(2010)Andersen, T., et al. J. Rheumatol. 36(4):757-759(2009)Ruskamp, J.M., et al. Clin. Exp. Immunol. 155(3):433-440(2009)Lacroix, M., et al. J. Immunol. 182(1):456-465(2009)Munthe-Fog, L., et al. Mol. Immunol. 45(9):2660-2666(2008)
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