|Other Names||NKG2-A/NKG2-B type II integral membrane protein, CD159 antigen-like family member A, NK cell receptor A, NKG2-A/B-activating NK receptor, CD159a, KLRC1, NKG2A|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role as a receptor for the recognition of MHC class I HLA-E molecules by NK cells and some cytotoxic T-cells.|
|Cellular Location||Membrane; Single-pass type II membrane protein|
|Tissue Location||Natural killer cells.|
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Natural killer (NK) cells are lymphocytes that can mediatelysis of certain tumor cells and virus-infected cells withoutprevious activation. They can also regulate specific humoral andcell-mediated immunity. The protein encoded by this gene belongs tothe killer cell lectin-like receptor family, also called NKG2family, which is a group of transmembrane proteins preferentiallyexpressed in NK cells. This family of proteins is characterized bythe type II membrane orientation and the presence of a C-typelectin domain. This protein forms a complex with another familymember, KLRD1/CD94, and has been implicated in the recognition ofthe MHC class I HLA-E molecules in NK cells. The genes of NKG2family members form a killer cell lectin-like receptor gene clusteron chromosome 12. Four alternatively spliced transcript variantsencoding two distinct isoforms have been observed. [provided byRefSeq].
Ucisik-Akkaya, E., et al. Mol. Hum. Reprod. 16(10):770-777(2010)Ma, J., et al. J. Med. Virol. 82(9):1501-1507(2010)Harrison, R.J., et al. Clin. Exp. Immunol. 161(2):306-314(2010)Rose, J.E., et al. Mol. Med. 16 (7-8), 247-253 (2010) :Beziat, V., et al. PLoS ONE 5 (8), E11966 (2010) :
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