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KIAA0319 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q5VV43 |
|---|---|
| Clone Names | 100318212 |
| Gene ID | 9856 |
|---|---|
| Other Names | Dyslexia-associated protein KIAA0319, KIAA0319 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | KIAA0319 |
|---|---|
| Function | Involved in neuronal migration during development of the cerebral neocortex. May function in a cell autonomous and a non-cell autonomous manner and play a role in appropriate adhesion between migrating neurons and radial glial fibers. May also regulate growth and differentiation of dendrites. |
| Cellular Location | Cell membrane; Single-pass type I membrane protein. Early endosome membrane; Single-pass type I membrane protein. Note=Low-abundance isoforms lacking the transmembrane domain have been described; these are secreted |
| Tissue Location | Detected in adult brain cortex and fetal frontal lobe (at protein level). Highly expressed in brain cortex, putamen, amygdala, hippocampus and cerebellum. |
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Provided below are standard protocols that you may find useful for product applications.
Background
The longest isoform encoded by this gene is atransmembrane protein that is both N- and O-glycosylated. Defectsin this gene may cause susceptibility to dyslexia type 2 (DYX2).Multiple transcript variants encoding several different isoformshave been found for this gene.
References
Lind, P.A., et al. Eur. J. Hum. Genet. 18(6):668-673(2010)Peschansky, V.J., et al. Cereb. Cortex 20(4):884-897(2010)Couto, J.M., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (2), 447-462 (2010) :Couto, J.M., et al. Biol. Psychiatry 66(4):368-375(2009)Levecque, C., et al. Am. J. Physiol., Cell Physiol. 297 (1), C160-C168 (2009) :
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