|Other Names||Keratin-associated protein 1-3, Keratin-associated protein 18, Keratin-associated protein 19, KRTAP1-3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high- sulfur and high-glycine-tyrosine keratins.|
|Tissue Location||Expressed in the middle/upper portions of the hair cortex, in the region termed the keratogenous zone|
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This protein is a member of the keratin-associated protein(KAP) family. The KAP proteins form a matrix of keratinintermediate filaments which contribute to the structure of hairfibers. KAP family members appear to have unique, family-specificamino- and carboxyl-terminal regions and are subdivided into threemulti-gene families according to amino acid composition: the highsulfur, the ultrahigh sulfur, and the high tyrosine/glycine KAPs.This protein is a member of the high sulfur KAP family and the geneis localized to a cluster of KAPs at 17q12-q21. [provided byRefSeq].
Shimomura, Y., et al. J. Biol. Chem. 277(47):45493-45501(2002)Rogers, M.A., et al. J. Biol. Chem. 276(22):19440-19451(2001)Zhumabaeva, B.D., et al. Mol. Biol. (Mosk.) 26(4):813-820(1992)
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