|Other Names||Mediator of RNA polymerase II transcription subunit 22, Mediator complex subunit 22, Surfeit locus protein 5, Surf-5, MED22, SURF5|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is located in the surfeit gene cluster, a groupof very tightly linked housekeeping genes that do not sharesequence similarity. The gene is oriented in a head-to-head fashionwith RPL7A (SURF3) and the two genes share a bidirectionalpromoter. The encoded proteins are localized to the cytoplasm. Twoalternative transcript variants encoding different isoforms havebeen identified for this gene.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Lamesch, P., et al. Genomics 89(3):307-315(2007)Sato, S., et al. Mol. Cell 14(5):685-691(2004)Hillman, R.T., et al. Genome Biol. 5 (2), R8 (2004) :
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