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GPS1 Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q13098
Clone Names 100318189
Peptide ID 100318189
Additional Information
Gene ID 2873
Other Names COP9 signalosome complex subunit 1, SGN1, Signalosome subunit 1, G protein pathway suppressor 1, GPS-1, JAB1-containing signalosome subunit 1, Protein MFH, GPS1, COPS1, CSN1
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GPS1
Synonyms COPS1, CSN1
Function Essential component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, c-jun/JUN, IkappaBalpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN- dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively. Suppresses G-protein- and mitogen-activated protein kinase-mediated signal transduction.
Cellular Location Cytoplasm. Nucleus
Tissue Location Widely expressed.
Research Areas
Citations (0)

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This gene is known to suppress G-protein andmitogen-activated signal transduction in mammalian cells. Theencoded protein shares significant similarity with ArabidopsisFUS6, which is a regulator of light-mediated signal transduction inplant cells. Two alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].


Matsuoka, S., et al. Science 316(5828):1160-1166(2007)Ewing, R.M., et al. Mol. Syst. Biol. 3, 89 (2007) :Olsen, J.V., et al. Cell 127(3):635-648(2006)Beausoleil, S.A., et al. Nat. Biotechnol. 24(10):1285-1292(2006)Wang, Y., et al. FEBS Lett. 572 (1-3), 85-91 (2004) :

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$ 80.00
Cat# BP12706c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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