Foundational characteristics of cancer include proliferation, angiogenesis, migration, evasion of apoptosis, and cellular immortality. Find key markers for these cellular processes and antibodies to detect them.
The SUMOplot™ Analysis Program predicts and scores sumoylation sites in your protein. SUMOylation is a post-translational modification involved in various cellular processes, such as nuclear-cytosolic transport, transcriptional regulation, apoptosis, protein stability, response to stress, and progression through the cell cycle.
The Autophagy Receptor Motif Plotter predicts and scores autophagy receptor binding sites in your protein. Identifying proteins connected to this pathway is critical to understanding the role of autophagy in physiological as well as pathological processes such as development, differentiation, neurodegenerative diseases, stress, infection, and cancer.
FBLIM1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8WUP2 |
|---|---|
| Clone Names | 100324053 |
| Gene ID | 54751 |
|---|---|
| Other Names | Filamin-binding LIM protein 1, FBLP-1, Migfilin, Mitogen-inducible 2-interacting protein, MIG2-interacting protein, FBLIM1, FBLP1 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | FBLIM1 |
|---|---|
| Synonyms | FBLP1 |
| Function | Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin-containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion. |
| Cellular Location | Cell junction, focal adhesion. Cytoplasm, cytoskeleton, stress fiber Note=Associated with actin stress fiber at cell-ECM focal adhesion sites (PubMed:12679033, PubMed:18829455). Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell- EMC adhesion sites through interaction with FERMT2 (PubMed:12679033) Isoform 2 is localized at actin stress fibers (PubMed:12496242) |
| Tissue Location | Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a protein with an N-terminalfilamin-binding domain, a central proline-rich domain, and,multiple C-terminal LIM domains. This protein localizes at celljunctions and may link cell adhesion structures to the actincytoskeleton. This protein may be involved in the assembly andstabilization of actin-filaments and likely plays a role inmodulating cell adhesion, cell morphology and cell motility. Thisprotein also localizes to the nucleus and may affect cardiomyocytedifferentiation after binding with the CSX/NKX2-5 transcriptionfactor. Alternative splicing results in multiple transcriptvariants encoding different isoforms.
References
Zhao, J., et al. J. Biol. Chem. 284(49):34308-34320(2009)Ithychanda, S.S., et al. J. Biol. Chem. 284(7):4713-4722(2009)Lad, Y., et al. J. Biol. Chem. 283(50):35154-35163(2008)Lai-Cheong, J.E., et al. J. Invest. Dermatol. 128(9):2156-2165(2008)Papachristou, D.J., et al. Histopathology 51(4):499-508(2007)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.
Ordering Information
Other Products
Shipping Information
