|Other Names||Filamin-binding LIM protein 1, FBLP-1, Migfilin, Mitogen-inducible 2-interacting protein, MIG2-interacting protein, FBLIM1, FBLP1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Serves as an anchoring site for cell-ECM adhesion proteins and filamin-containing actin filaments. Is implicated in cell shape modulation (spreading) and motility. May participate in the regulation of filamin-mediated cross-linking and stabilization of actin filaments. May also regulate the assembly of filamin- containing signaling complexes that control actin assembly. Promotes dissociation of FLNA from ITGB3 and ITGB7. Promotes activation of integrins and regulates integrin-mediated cell-cell adhesion.|
|Cellular Location||Cytoplasm, cell cortex. Cell junction, focal adhesion. Cytoplasm, cytoskeleton. Note=Associated with actin stress fiber at cell-ECM focal adhesion sites. Isoform 1 and isoform 3 are recruited and localized at actin stress fibers and clustered at cell-EMC adhesion sites through interaction with FERMT2. Isoform 2 is localized at actin stress fibers|
|Tissue Location||Isoform 1 and isoform 3 are expressed in heart, kidney, lung, pancreas, placenta and platelets. Isoform 2 is expressed in brain, heart, kidney, lung, pancreas, placenta, skeletal muscle and platelets.|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a protein with an N-terminalfilamin-binding domain, a central proline-rich domain, and,multiple C-terminal LIM domains. This protein localizes at celljunctions and may link cell adhesion structures to the actincytoskeleton. This protein may be involved in the assembly andstabilization of actin-filaments and likely plays a role inmodulating cell adhesion, cell morphology and cell motility. Thisprotein also localizes to the nucleus and may affect cardiomyocytedifferentiation after binding with the CSX/NKX2-5 transcriptionfactor. Alternative splicing results in multiple transcriptvariants encoding different isoforms.
Zhao, J., et al. J. Biol. Chem. 284(49):34308-34320(2009)Ithychanda, S.S., et al. J. Biol. Chem. 284(7):4713-4722(2009)Lad, Y., et al. J. Biol. Chem. 283(50):35154-35163(2008)Lai-Cheong, J.E., et al. J. Invest. Dermatol. 128(9):2156-2165(2008)Papachristou, D.J., et al. Histopathology 51(4):499-508(2007)
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