|Other Names||Protein RIC-3, Resistant to inhibitor of cholinesterase 3, RIC3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes functional expression of homomeric alpha-7 and alpha-8 nicotinic acetylcholine receptors at the cell surface. May also promote functional expression of homomeric serotoninergic 5- HT3 receptors, and of heteromeric acetylcholine receptors alpha- 3/beta-2, alpha-3/beta-4, alpha-4/beta-2 and alpha-4/beta-4.|
|Cellular Location||Isoform 1: Endoplasmic reticulum membrane; Single-pass membrane protein|
|Tissue Location||Broadly expressed, with high levels in muscle, brain, heart, pancreas and testis. In the central nervous system, highest levels are detected in the cerebellum and pituitary gland Over-expressed in brains from patients with bipolar disease or schizophrenia. Isoform 5 is predominantly expressed in the brain|
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RIC3 is a protein associated with nicotinic acetylcholinereceptors (nAChRs), neurotransmitter-gated ion channels expressedat the neuromuscular junction and within the central and peripheralnervous systems, that can enhance functional expression of multiplenAChR subtypes (Lansdell et al., 2005 [PubMed 16120769]).[suppliedby OMIM].
Walstab, J., et al. J. Biol. Chem. 285(35):26956-26965(2010)Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Seredenina, T., et al. Biosci. Rep. 28(6):299-306(2008)Roncarati, R., et al. Assay Drug Dev Technol 6(2):181-193(2008)
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