|Other Names||Fibroblast growth factor receptor-like 1, FGF receptor-like protein 1, FGF homologous factor receptor, FGFR-like protein, Fibroblast growth factor receptor 5, FGFR-5, FGFRL1, FGFR5, FHFR|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Has a negative effect on cell proliferation.|
|Cellular Location||Membrane; Single-pass type I membrane protein Note=Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles|
|Tissue Location||Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.|
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The protein encoded by this gene is a member of thefibroblast growth factor receptor (FGFR) family, where amino acidsequence is highly conserved between members and throughoutevolution. FGFR family members differ from one another in theirligand affinities and tissue distribution. A full-lengthrepresentative protein would consist of an extracellular region,composed of three immunoglobulin-like domains, a single hydrophobicmembrane-spanning segment and a cytoplasmic tyrosine kinase domain.The extracellular portion of the protein interacts with fibroblastgrowth factors, setting in motion a cascade of downstream signals,ultimately influencing mitogenesis and differentiation. A markeddifference between this gene product and the other family membersis its lack of a cytoplasmic tyrosine kinase domain. The result isa transmembrane receptor that could interact with other familymembers and potentially inhibit signaling. Multiple alternativelyspliced transcript variants encoding the same isoform have beenfound for this gene.
Bailey, S.D., et al. Diabetes Care (2010) In press :Liu, C.Y., et al. Carcinogenesis 31(7):1259-1263(2010)LopezJimenez, N., et al. Hum. Genet. 127(3):325-336(2010)Steinberg, F., et al. J. Biol. Chem. 285(3):2193-2202(2010)Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)
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