|Other Names||Transcription termination factor 1, TTF-1, RNA polymerase I termination factor, Transcription termination factor I, TTF-I, TTF1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity.|
|Cellular Location||Nucleus. Nucleus, nucleolus.|
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Provided below are standard protocols that you may find useful for product applications.
The TTF1 gene encodes a transcription termination factorthat regulates ribosomal gene transcription (summarized by Green etal., 2010 [PubMed 20448178]).
Montanelli, L., et al. Mol. Cell. Endocrinol. 322 (1-2), 64-71 (2010) :Lessard, F., et al. Mol. Cell 38(4):539-550(2010)Green, R.E., et al. Science 328(5979):710-722(2010)McCluggage, W.G., et al. Am. J. Surg. Pathol. 34(4):525-532(2010)Kreil, S., et al. Leuk. Res. 33 (9), E168-E169 (2009) :
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