TTF-1 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q15361 |
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Clone Names | 80722105 |
Gene ID | 7270 |
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Other Names | Transcription termination factor 1, TTF-1, RNA polymerase I termination factor, Transcription termination factor I, TTF-I, TTF1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TTF1 |
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Function | Multifunctional nucleolar protein that terminates ribosomal gene transcription, mediates replication fork arrest and regulates RNA polymerase I transcription on chromatin. Plays a dual role in rDNA regulation, being involved in both activation and silencing of rDNA transcription. Interaction with BAZ2A/TIP5 recovers DNA-binding activity. |
Cellular Location | Nucleus {ECO:0000250|UniProtKB:Q62187}. Nucleus, nucleolus {ECO:0000250|UniProtKB:Q62187}. Nucleus, nucleoplasm {ECO:0000250|UniProtKB:Q62187}. Note=May be localized to the nucleolus in an NPM1/B23-dependent manner. May be displaced from the nucleolus into the nucleoplasm in an CDKN2A/ARF-dependent manner. May shuttle back and forth from nucleoplasm to nucleolus {ECO:0000250|UniProtKB:Q62187} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The TTF1 gene encodes a transcription termination factorthat regulates ribosomal gene transcription (summarized by Green etal., 2010 [PubMed 20448178]).
References
Montanelli, L., et al. Mol. Cell. Endocrinol. 322 (1-2), 64-71 (2010) :Lessard, F., et al. Mol. Cell 38(4):539-550(2010)Green, R.E., et al. Science 328(5979):710-722(2010)McCluggage, W.G., et al. Am. J. Surg. Pathol. 34(4):525-532(2010)Kreil, S., et al. Leuk. Res. 33 (9), E168-E169 (2009) :
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