CCR1 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | P32246 |
---|---|
Clone Names | 90723161 |
Gene ID | 1230 |
---|---|
Other Names | C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, RANTES-R, CD191, CCR1, CMKBR1, CMKR1, SCYAR1 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | CCR1 |
---|---|
Synonyms | CMKBR1, CMKR1, SCYAR1 |
Function | Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP- 1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1-beta or MCP- 1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation. |
Cellular Location | Cell membrane; Multi-pass membrane protein |
Tissue Location | Widely expressed in different hematopoietic cells. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
This gene encodes a member of the beta chemokine receptorfamily, which is predicted to be a seven transmembrane proteinsimilar to G protein-coupled receptors. The ligands of thisreceptor include macrophage inflammatory protein 1 alpha (MIP-1alpha), regulated on activation normal T expressed and secretedprotein (RANTES), monocyte chemoattractant protein 3 (MCP-3), andmyeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines andtheir receptors mediated signal transduction are critical for therecruitment of effector immune cells to the site of inflammation.Knockout studies of the mouse homolog suggested the roles of thisgene in host protection from inflammatory response, andsusceptibility to virus and parasite. This gene and other chemokinereceptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, arefound to form a gene cluster on chromosome 3p. [provided byRefSeq].
References
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ohri, C.M., et al. BMC Cancer 10, 172 (2010) :
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.