|Other Names||C-C chemokine receptor type 1, C-C CKR-1, CC-CKR-1, CCR-1, CCR1, HM145, LD78 receptor, Macrophage inflammatory protein 1-alpha receptor, MIP-1alpha-R, RANTES-R, CD191, CCR1, CMKBR1, CMKR1, SCYAR1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Synonyms||CMKBR1, CMKR1, SCYAR1|
|Function||Receptor for a C-C type chemokine. Binds to MIP-1-alpha, MIP-1-delta, RANTES, and MCP-3 and, less efficiently, to MIP-1- beta or MCP-1 and subsequently transduces a signal by increasing the intracellular calcium ions level. Responsible for affecting stem cell proliferation.|
|Cellular Location||Cell membrane; Multi-pass membrane protein|
|Tissue Location||Widely expressed in different hematopoietic cells|
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This gene encodes a member of the beta chemokine receptorfamily, which is predicted to be a seven transmembrane proteinsimilar to G protein-coupled receptors. The ligands of thisreceptor include macrophage inflammatory protein 1 alpha (MIP-1alpha), regulated on activation normal T expressed and secretedprotein (RANTES), monocyte chemoattractant protein 3 (MCP-3), andmyeloid progenitor inhibitory factor-1 (MPIF-1). Chemokines andtheir receptors mediated signal transduction are critical for therecruitment of effector immune cells to the site of inflammation.Knockout studies of the mouse homolog suggested the roles of thisgene in host protection from inflammatory response, andsusceptibility to virus and parasite. This gene and other chemokinereceptor genes, including CCR2, CCRL2, CCR3, CCR5 and CCXCR1, arefound to form a gene cluster on chromosome 3p. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Han, S., et al. Hum. Immunol. 71(7):727-730(2010)Rajaraman, P., et al. Cancer Epidemiol. Biomarkers Prev. 19(5):1356-1361(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :Ohri, C.M., et al. BMC Cancer 10, 172 (2010) :
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