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SULF2 Antibody (C-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8IWU5 |
|---|---|
| Clone Names | 100318244 |
| Gene ID | 55959 |
|---|---|
| Other Names | Extracellular sulfatase Sulf-2, hSulf-2, 316-, SULF2, KIAA1247 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | SULF2 |
|---|---|
| Synonyms | KIAA1247 |
| Function | Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity (PubMed:12368295, PubMed:30788513, PubMed:35294879). It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin (PubMed:12368295, PubMed:30788513, PubMed:35294879). |
| Cellular Location | Endoplasmic reticulum {ECO:0000250|UniProtKB:Q8VI60}. Golgi apparatus, Golgi stack {ECO:0000250|UniProtKB:Q8VI60}. Cell surface |
| Tissue Location | Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta |
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Provided below are standard protocols that you may find useful for product applications.
Background
Heparan sulfate proteoglycans (HSPGs) act as coreceptorsfor numerous heparin-binding growth factors and cytokines and areinvolved in cell signaling. Heparan sulfate 6-O-endosulfatases,such as SULF2, selectively remove 6-O-sulfate groups from heparansulfate. This activity modulates the effects of heparan sulfate byaltering binding sites for signaling molecules (Dai et al., 2005[PubMed 16192265]).
References
Lai, J.P., et al. Hepatology 52(5):1680-1689(2010)Ellinor, P.T., et al. Nat. Genet. 42(3):240-244(2010)Lemjabbar-Alaoui, H., et al. Oncogene 29(5):635-646(2010)Tang, R., et al. J. Biol. Chem. 284(32):21505-21514(2009)Chau, B.N., et al. Cancer Res. 69(4):1368-1374(2009)
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