|Other Names||Extracellular sulfatase Sulf-2, hSulf-2, 316-, SULF2, KIAA1247|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|
|Cellular Location||Endoplasmic reticulum. Golgi apparatus, Golgi stack. Cell surface Note=Also localized on the cell surface.|
|Tissue Location||Expressed at highest levels in the ovary, skeletal muscle, stomach, brain, uterus, heart, kidney and placenta|
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Provided below are standard protocols that you may find useful for product applications.
Heparan sulfate proteoglycans (HSPGs) act as coreceptorsfor numerous heparin-binding growth factors and cytokines and areinvolved in cell signaling. Heparan sulfate 6-O-endosulfatases,such as SULF2, selectively remove 6-O-sulfate groups from heparansulfate. This activity modulates the effects of heparan sulfate byaltering binding sites for signaling molecules (Dai et al., 2005[PubMed 16192265]).
Lai, J.P., et al. Hepatology 52(5):1680-1689(2010)Ellinor, P.T., et al. Nat. Genet. 42(3):240-244(2010)Lemjabbar-Alaoui, H., et al. Oncogene 29(5):635-646(2010)Tang, R., et al. J. Biol. Chem. 284(32):21505-21514(2009)Chau, B.N., et al. Cancer Res. 69(4):1368-1374(2009)
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