|Other Names||Kinetochore-associated protein DSN1 homolog, DSN1, C20orf172, MIS13|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Part of the MIS12 complex which is required for normal chromosome alignment and segregation and kinetochore formation during mitosis.|
|Cellular Location||Nucleus. Chromosome, centromere, kinetochore Note=Associated with the kinetochore|
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This gene encodes a kinetochore protein that functions aspart of the minichromosome instability-12 centromere complex. Theencoded protein is required for proper kinetochore assembly andprogression through the cell cycle. Alternative splicing results inmultiple transcript variants.
Yang, Y., et al. J. Biol. Chem. 283(39):26726-26736(2008)Cheeseman, I.M., et al. Nat. Rev. Mol. Cell Biol. 9(1):33-46(2008)Kiyomitsu, T., et al. Dev. Cell 13(5):663-676(2007)Lamesch, P., et al. Genomics 89(3):307-315(2007)Kline, S.L., et al. J. Cell Biol. 173(1):9-17(2006)
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