|Other Names||S-methylmethionine--homocysteine S-methyltransferase BHMT2, SMM-hcy methyltransferase, Betaine--homocysteine S-methyltransferase 2, BHMT2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Involved in the regulation of homocysteine metabolism. Converts homocysteine to methionine using S-methylmethionine (SMM) as a methyl donor.|
|Tissue Location||Expressed in liver and kidney and at reduced levels in the brain, heart, and skeletal muscle|
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Provided below are standard protocols that you may find useful for product applications.
Homocysteine is a sulfur-containing amino acid that playsa crucial role in methylation reactions. Transfer of the methylgroup from betaine to homocysteine creates methionine, whichdonates the methyl group to methylate DNA, proteins, lipids, andother intracellular metabolites. The protein encoded by this geneis one of two methyl transferases that can catalyze the transfer ofthe methyl group from betaine to homocysteine. Anomalies inhomocysteine metabolism have been implicated in disorders rangingfrom vascular disease to neural tube birth defects such as spinabifida. Alternatively spliced transcript variants encodingdifferent isoforms have been found for this gene. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Giusti, B., et al. Thromb. Haemost. 104(2):231-242(2010)Mostowska, A., et al. Eur. J. Oral Sci. 118(4):325-332(2010)Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) :McGeachie, M., et al. Circulation 120(24):2448-2454(2009)
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