|Other Names||Sperm-associated antigen 8, HSD-1, Sperm membrane protein 1, SMP-1, Sperm membrane protein BS-84, SPAG8|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in fertility and microtubule formation through interaction with RANBP9.|
|Cellular Location||Cytoplasmic vesicle, secretory vesicle, acrosome. Note=Acrosomal region of the head of mature sperm cells|
|Tissue Location||Expressed in testis (germ cells), but not in liver, kidney, prostate and small intestine|
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Provided below are standard protocols that you may find useful for product applications.
The correlation of anti-sperm antibodies with cases ofunexplained infertility implicates a role for these antibodies inblocking fertilization. Improved diagnosis and treatment ofimmunologic infertility, as well as identification of proteins fortargeted contraception, are dependent on the identification andcharacterization of relevant sperm antigens. The protein encoded bythis gene is recognized by sperm agglutinating antibodies from aninfertile woman. This protein is localized in germ cells of thetestis at all stages of spermatogenesis and is localized to theacrosomal region of mature spermatozoa. Alternatively splicedvariants that encode different protein isoforms have been describedbut the full-length sequences of only two have been determined.
Wu, H., et al. FEBS Lett. 584(13):2807-2815(2010)Li, R., et al. Cell Biochem. Funct. 27(5):264-268(2009)Cheng, G.Y., et al. Asian J. Androl. 9(1):23-29(2007)Tang, X., et al. J. Mol. Med. 82(6):383-388(2004)Humphray, S.J., et al. Nature 429(6990):369-374(2004)
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