|Other Names||Equilibrative nucleoside transporter 3, hENT3, Solute carrier family 29 member 3, SLC29A3, ENT3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Mediates both influx and efflux of nucleosides across the membrane (equilibrative transporter). Mediates transport of adenine, adenosine and uridine, as well as several nucleoside analog drugs, such as anticancer and antiviral agents, including cladribine, cordycepin, tubercidin and AZT. Does not transport hypoxanthine.|
|Cellular Location||Membrane; Multi-pass membrane protein. Late endosome membrane. Lysosome membrane. Note=Observed in a punctate intracellular pattern showing partial colocalization with late endosomes/lysosomes. Not detected at the cell surface|
|Tissue Location||Widely expressed in both adult and fetal tissues. Highest levels in placenta, uterus, ovary, spleen, lymph node and bone marrow. Lowest levels in brain and heart|
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This gene encodes a nucleoside transporter. The encodedprotein plays a role in cellular uptake of nucleosides,nucleobases, and their related analogs. Mutations in this gene havebeen associated with H syndrome, which is characterized bycutaneous hyperpigmentation and hypertrichosis, hepatosplenomegaly,heart anomalies, and hypogonadism. A related disorder, PHID(pigmented hypertrichosis with insulin-dependent diabetesmellitus), has also been associated with mutations at this locus.Alternatively spliced transcript variants have been described.
Gass, N., et al. J Affect Disord 126 (1-2), 134-139 (2010) :Kang, N., et al. J. Biol. Chem. 285(36):28343-28352(2010)Li, X., et al. Zhongguo Fei Ai Za Zhi 13(5):458-463(2010)Priya, T.P., et al. Br. J. Dermatol. 162(5):1132-1134(2010)Cliffe, S.T., et al. Hum. Mol. Genet. 18(12):2257-2265(2009)
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