|Other Names||E3 ubiquitin-protein ligase ZFP91, 632-, Zinc finger protein 757, Zinc finger protein 91 homolog, Zfp-91, ZFP91, ZNF757|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Atypical E3 ubiquitin-protein ligase that mediates 'Lys- 63'-linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non- canonical NF-kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis.|
|Tissue Location||Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific|
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abgent to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
email@example.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
The protein encoded by this gene is a member of the zincfinger family of proteins. The gene product contains C2H2-typedomains, which are the classical zinc finger domains found innumerous nucleic acid-binding proteins. This protein functions as aregulator of the non-canonical NF-kappaB pathway inlymphotoxin-beta receptor signaling. Alternative splicing resultsin multiple transcript variants. A read-through transcript variantcomposed of ZFP91 and the downstream CNTF gene sequence has beenidentified, but it is thought to be non-coding. Read-throughtranscription of ZFP91 and CNTF has also been observed in mouse. AZFP91-related pseudogene has also been identified on chromosome 2.
Jin, H.R., et al. Biochem. Biophys. Res. Commun. 400(4):581-586(2010)Jin, X., et al. J. Biol. Chem. 285(40):30539-30547(2010)Kiem, H.P., et al. Exp. Hematol. 38(9):819-822(2010)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
If you have used an Abgent product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at firstname.lastname@example.org.