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ZFP91 Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q96JP5 |
|---|---|
| Clone Names | 110111045 |
| Gene ID | 80829 |
|---|---|
| Other Names | E3 ubiquitin-protein ligase ZFP91, 632-, Zinc finger protein 757, Zinc finger protein 91 homolog, Zfp-91, ZFP91, ZNF757 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | ZFP91 |
|---|---|
| Synonyms | ZNF757 |
| Function | Atypical E3 ubiquitin-protein ligase that mediates 'Lys-63'- linked ubiquitination of MAP3K14/NIK, leading to stabilize and activate MAP3K14/NIK. It thereby acts as an activator of the non-canonical NF- kappa-B2/NFKB2 pathway. May also play an important role in cell proliferation and/or anti-apoptosis. |
| Cellular Location | Nucleus. |
| Tissue Location | Expressed ubiquitously, particularly at high level in testis. Isoform 2 is testis specific |
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Provided below are standard protocols that you may find useful for product applications.
Background
The protein encoded by this gene is a member of the zincfinger family of proteins. The gene product contains C2H2-typedomains, which are the classical zinc finger domains found innumerous nucleic acid-binding proteins. This protein functions as aregulator of the non-canonical NF-kappaB pathway inlymphotoxin-beta receptor signaling. Alternative splicing resultsin multiple transcript variants. A read-through transcript variantcomposed of ZFP91 and the downstream CNTF gene sequence has beenidentified, but it is thought to be non-coding. Read-throughtranscription of ZFP91 and CNTF has also been observed in mouse. AZFP91-related pseudogene has also been identified on chromosome 2.
References
Jin, H.R., et al. Biochem. Biophys. Res. Commun. 400(4):581-586(2010)Jin, X., et al. J. Biol. Chem. 285(40):30539-30547(2010)Kiem, H.P., et al. Exp. Hematol. 38(9):819-822(2010)Sugiyama, N., et al. Mol. Cell Proteomics 6(6):1103-1109(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
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