|Other Names||Cathepsin K, Cathepsin O, Cathepsin O2, Cathepsin X, CTSK, CTSO, CTSO2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Closely involved in osteoclastic bone resorption and may participate partially in the disorder of bone remodeling. Displays potent endoprotease activity against fibrinogen at acid pH. May play an important role in extracellular matrix degradation.|
|Tissue Location||Predominantly expressed in osteoclasts (bones)|
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The protein encoded by this gene is a lysosomal cysteineproteinase involved in bone remodeling and resorption. Thisprotein, which is a member of the peptidase C1 protein family, ispredominantly expressed in osteoclasts. However, the encodedprotein is also expressed in a significant fraction of human breastcancers, where it could contribute to tumor invasiveness. Mutationsin this gene are the cause of pycnodysostosis, an autosomalrecessive disease characterized by osteosclerosis and shortstature. This gene may be subject to RNA editing. [provided byRefSeq].
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Novinec, M., et al. Biochem. J. 429(2):379-389(2010)Khan, B., et al. J. Investig. Med. 58(5):720-724(2010)Johnatty, S.E., et al. PLoS Genet. 6 (7), E1001016 (2010) :Szumilo, J., et al. Folia Histochem. Cytobiol. 47(4):571-578(2009)
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