|Other Names||Glutaryl-CoA dehydrogenase, mitochondrial, GCD, GCDH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes the oxidative decarboxylation of glutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathway of L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It uses electron transfer flavoprotein as its electron acceptor. Isoform Short is inactive.|
|Cellular Location||Mitochondrion matrix.|
|Tissue Location||Isoform Long and isoform Short are expressed in fibroblasts and liver|
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The protein encoded by this gene belongs to the acyl-CoAdehydrogenase family. It catalyzes the oxidative decarboxylation ofglutaryl-CoA to crotonyl-CoA and CO(2) in the degradative pathwayof L-lysine, L-hydroxylysine, and L-tryptophan metabolism. It useselectron transfer flavoprotein as its electron acceptor. The enzymeexists in the mitochondrial matrix as a homotetramer of 45-kDsubunits. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.
Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010)Park, J.D., et al. J. Korean Med. Sci. 25(6):957-960(2010)Strauss, K.A., et al. Brain 133 (PT 1), 76-92 (2010) :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Ganesh, S.K., et al. Nat. Genet. 41(11):1191-1198(2009)
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