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PPARA Antibody (Center) Blocking peptide

Synthetic peptide

Product Information
Primary Accession Q07869
Clone Names 90625188
Peptide ID 90625188
Additional Information
Gene ID 5465
Other Names Peroxisome proliferator-activated receptor alpha, PPAR-alpha, Nuclear receptor subfamily 1 group C member 1, PPARA, NR1C1, PPAR
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Synonyms NR1C1, PPAR
Function Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl- 2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.
Cellular Location Nucleus.
Tissue Location Skeletal muscle, liver, heart and kidney.
Research Areas
Citations (0)

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Peroxisome proliferators include hypolipidemic drugs,herbicides, leukotriene antagonists, and plasticizers; this termarises because they induce an increase in the size and number ofperoxisomes. Peroxisomes are subcellular organelles found in plantsand animals that contain enzymes for respiration and forcholesterol and lipid metabolism. The action of peroxisomeproliferators is thought to be mediated via specific receptors,called PPARs, which belong to the steroid hormone receptorsuperfamily. PPARs affect the expression of target genes involvedin cell proliferation, cell differentiation and in immune andinflammation responses. Three closely related subtypes (alpha,beta/delta, and gamma) have been identified. This gene encodes thesubtype PPAR-alpha, which is a nuclear transcription factor.Multiple alternatively spliced transcript variants have beendescribed for this gene, although the full-length nature of onlytwo has been determined.


Jablonski, K.A., et al. Diabetes 59(10):2672-2681(2010)Hu, M., et al. Pharmacogenet. Genomics 20(10):634-637(2010)Romero, R., et al. Am. J. Obstet. Gynecol. 203 (4), 361 (2010) :Eynon, N., et al. Mitochondrion (2010) In press :Aldhoon, B., et al. Folia Biol. (Praha) 56(3):116-123(2010)

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$ 80.00
Cat# BP12910c
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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