|Other Names||Plakophilin-2, PKP2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May play a role in junctional plaques.|
|Cellular Location||Nucleus. Cell junction, desmosome. Note=Nuclear and associated with desmosomes|
|Tissue Location||Detected in heart right ventricle (at protein level). Widely expressed. Found at desmosomal plaques in simple and stratified epithelia and in non-epithelial tissues such as myocardium and lymph node follicles. In most stratified epithelia found in the desmosomes of the basal cell layer and seems to be absent from suprabasal strata.|
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This gene encodes a member of the arm-repeat (armadillo)and plakophilin gene families. Plakophilin proteins containnumerous armadillo repeats, localize to cell desmosomes and nuclei,and participate in linking cadherins to intermediate filaments inthe cytoskeleton. This gene product may regulate the signalingactivity of beta-catenin. Two alternately spliced transcriptsencoding two protein isoforms have been identified. A processedpseudogene with high similarity to this locus has been mapped tochromosome 12p13.
Fressart, V., et al. Europace 12(6):861-868(2010)Cox, M.G., et al. Circ Arrhythm Electrophysiol 3(2):126-133(2010)Christensen, A.H., et al. Cardiology 115(2):148-154(2010)den Haan, A.D., et al. Circ Cardiovasc Genet 2(5):428-435(2009)Bhuiyan, Z.A., et al. Circ Cardiovasc Genet 2(5):418-427(2009)
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