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TLE4 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q04727
Clone Names 101008166
Peptide ID 101008166
Additional Information
Gene ID 7091
Other Names Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4, TLE4, GRG4, KIAA1261
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name TLE4
Synonyms GRG4, KIAA1261
Function Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).
Cellular Location Nucleus.
Tissue Location In all tissues examined, mostly in brain, and muscle
Research Areas
Citations (0)

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Background

TLE4 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).

References

Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :Hancock, D.B., et al. PLoS Genet. 5 (8), E1000623 (2009) :Stolk, L., et al. Nat. Genet. (2009) In press :Dayyani, F., et al. Blood 111(8):4338-4347(2008)Heimbucher, T., et al. Mol. Cell. Biol. 27(1):340-351(2007)

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$ 80.00
Cat# BP12953a
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