TLE4 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q04727 |
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Clone Names | 101008166 |
Gene ID | 7091 |
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Other Names | Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4, TLE4, GRG4, KIAA1261 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | TLE4 |
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Synonyms | GRG4, KIAA1261 |
Function | Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity). Involved in transcriptional repression of GNRHR and enhances MSX1-mediated transcriptional repression of CGA/alpha-GSU (By similarity). |
Cellular Location | Nucleus. |
Tissue Location | In all tissues examined, mostly in brain, and muscle |
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Provided below are standard protocols that you may find useful for product applications.
Background
TLE4 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
References
Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :Hancock, D.B., et al. PLoS Genet. 5 (8), E1000623 (2009) :Stolk, L., et al. Nat. Genet. (2009) In press :Dayyani, F., et al. Blood 111(8):4338-4347(2008)Heimbucher, T., et al. Mol. Cell. Biol. 27(1):340-351(2007)
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