|Other Names||Transducin-like enhancer protein 4, Grg-4, Groucho-related protein 4, TLE4, GRG4, KIAA1261|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES. Essential for the transcriptional repressor activity of SIX3 during retina and lens development and for SIX3 transcriptional auto-repression (By similarity).|
|Tissue Location||In all tissues examined, mostly in brain, and muscle|
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TLE4 is a transcriptional corepressor that binds to a number of transcription factors. Inhibits the transcriptional activation mediated by PAX5, and by CTNNB1 and TCF family members in Wnt signaling. The effects of full-length TLE family members may be modulated by association with dominant-negative AES (By similarity).
Liu, Y., et al. PLoS Genet. 5 (11), E1000707 (2009) :Hancock, D.B., et al. PLoS Genet. 5 (8), E1000623 (2009) :Stolk, L., et al. Nat. Genet. (2009) In press :Dayyani, F., et al. Blood 111(8):4338-4347(2008)Heimbucher, T., et al. Mol. Cell. Biol. 27(1):340-351(2007)
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