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SIM1 Antibody (N-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P81133
Clone Names 100324039
Peptide ID 100324039
Additional Information
Other Names Single-minded homolog 1, Class E basic helix-loop-helix protein 14, bHLHe14, SIM1, BHLHE14
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name SIM1
Synonyms BHLHE14
Function Transcriptional factor that may have pleiotropic effects during embryogenesis and in the adult.
Cellular Location Nucleus {ECO:0000255|PROSITE- ProRule:PRU00632, ECO:0000255|PROSITE-ProRule:PRU00981} EMBL; U70212; AAB62395.1; -; mRNA EMBL; AL121948; -; NOT_ANNOTATED_CDS; Genomic_DNA EMBL; Z86062; -; NOT_ANNOTATED_CDS; Genomic_DNA CCDS; CCDS5045.1; - RefSeq; NP_005059.2; NM_005068.2 RefSeq; XP_005267157.1; XM_005267100.2 RefSeq; XP_016866686.1; XM_017011197.1 UniGene; Hs.520293; - UniGene; Hs.735754; - ProteinModelPortal; P81133; - SMR; P81133; - BioGrid; 112383; 2 IntAct; P81133; 1 STRING; 9606.ENSP00000262901; - iPTMnet; P81133; - PhosphoSitePlus; P81133; - BioMuta; SIM1; - DMDM; 109940166; - PaxDb; P81133; - PeptideAtlas; P81133; - PRIDE; P81133; - ProteomicsDB; 57691; - DNASU; 6492; - Ensembl; ENST00000262901; ENSP00000262901; ENSG00000112246 Ensembl; ENST00000369208; ENSP00000358210; ENSG00000112246 GeneID; 6492; - KEGG; hsa:6492; - UCSC; uc063qgu.1; human CTD; 6492; - DisGeNET; 6492; - EuPathDB; HostDB:ENSG00000112246.9; - GeneCards; SIM1; - HGNC; HGNC:10882; SIM1 HPA; HPA024385; - MalaCards; SIM1; - MIM; 603128; gene neXtProt; NX_P81133; - OpenTargets; ENSG00000112246; - Orphanet; 171829; 6q16 deletion syndrome Orphanet; 369873; Obesity due to SIM1 deficiency Orphanet; 398079; Prader-Willi-like syndrome due to point mutation PharmGKB; PA35782; - eggNOG; KOG3559; Eukaryota eggNOG; ENOG410XY57; LUCA GeneTree; ENSGT00760000118788; - HOGENOM; HOG000236298; - HOVERGEN; HBG003936; - InParanoid; P81133; - KO; K09100; - OMA; ISPNCFG; - OrthoDB; EOG091G06FQ; - PhylomeDB; P81133; - TreeFam; TF317772; - SIGNOR; P81133; - ChiTaRS; SIM1; human GeneWiki; SIM1; - GenomeRNAi; 6492; - PRO; PR:P81133; - Proteomes; UP000005640; Chromosome 6 Bgee; ENSG00000112246; - CleanEx; HS_SIM1; - Genevisible; P81133; HS GO; GO:0005634; C:nucleus; IBA:GO_Central GO; GO:0003677; F:DNA binding; TAS:ProtInc GO; GO:0003700; F:DNA binding transcription factor activity; TAS:ProtInc GO; GO:0046982; F:protein heterodimerization activity; ISS:UniProtKB GO; GO:0000981; F:RNA polymerase II transcription factor activity, sequence-specific DNA binding; ISA:NTNU_SB GO; GO:0030154; P:cell differentiation; IEA:UniProtKB-KW GO; GO:0007399; P:nervous system development; IBA:GO_Central GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central GO; GO:0006351; P:transcription, DNA-templated; IEA:UniProtKB-KW GO; GO:0001657; P:ureteric bud development; IEA:Ensembl CDD; cd00083; HLH; 1 CDD; cd00130; PAS; 2 Gene3D; 4.10.280.10; -; 1 InterPro; IPR011598; bHLH_dom InterPro; IPR036638; HLH_DNA-bd_sf InterPro; IPR001610; PAC InterPro; IPR000014; PAS InterPro; IPR035965; PAS-like_dom_sf InterPro; IPR013767; PAS_fold InterPro; IPR013655; PAS_fold_3 InterPro; IPR010578; SIM_C Pfam; PF00010; HLH; 1 Pfam; PF00989; PAS; 1 Pfam; PF08447; PAS_3; 1 Pfam; PF06621; SIM_C; 1 SMART; SM00353; HLH; 1 SMART; SM00086; PAC; 1 SMART; SM00091; PAS; 2 SUPFAM; SSF47459; SSF47459; 1 SUPFAM; SSF55785; SSF55785; 2 PROSITE; PS50888; BHLH; 1 PROSITE; PS50112; PAS; 2 PROSITE; PS51302; SIM_C; 1 2: Evidence at transcript level; Complete proteome; Developmental protein; Differentiation; DNA-binding; Neurogenesis; Nucleus; Polymorphism; Reference proteome; Repeat; Transcription; Transcription regulation CHAIN 1 766 Single-minded homolog 1 /FTId=PRO_0000127439 DOMAIN 1 53 bHLH. {ECO:0000255|PROSITE- ProRule:PRU00981} DOMAIN 77 147 PAS 1. {ECO:0000255|PROSITE- ProRule:PRU00140} DOMAIN 218 288 PAS 2. {ECO:0000255|PROSITE- ProRule:PRU00140} DOMAIN 292 335 PAC DOMAIN 336 766 Single-minded C-terminal {ECO:0000255|PROSITE-ProRule:PRU00632} MOTIF 368 387 Nuclear localization signal VARIANT 175 175 L -> F (in dbSNP:rs438766) /FTId=VAR_049549 VARIANT 352 352 P -> T (in dbSNP:rs3734354) /FTId=VAR_034496 VARIANT 371 371 A -> V (in dbSNP:rs3734355) /FTId=VAR_034497 CONFLICT 30 30 P -> A (in Ref. 1; AAB62395) CONFLICT 37 37 L -> V (in Ref. 1; AAB62395) SEQUENCE 766 AA; 85515 MW; 05988D428A84431F CRC64; MKEKSKNAAR TRREKENSEF YELAKLLPLP SAITSQLDKA SIIRLTTSYL KMRVVFPEGL GEAWGHSSRT SPLDNVGREL GSHLLQTLDG FIFVVAPDGK IMYISETASV HLGLSQVELT GNSIYEYIHP ADHDEMTAVL TAHQPYHSHF VQEYEIERSF FLRMKCVLAK RNAGLTCGGY KVIHCSGYLK IRQYSLDMSP FDGCYQNVGL VAVGHSLPPS AVTEIKLHSN MFMFRASLDM KLIFLDSRVA ELTGYEPQDL IEKTLYHHVH GCDTFHLRCA HHLLLVKGQV TTKYYRFLAK HGGWVWVQSY ATIVHNSRSS RPHCIVSVNY VLTDTEYKGL QLSLDQISAS KPAFSYTSSS TPTMTDNRKG AKSRLSSSKS KSRTSPYPQY SGFHTERSES DHDSQWGGSP LTDTASPQLL DPADRPGSQH DASCAYRQFS DRSSLCYGFA LDHSRLVEER HFHTQACEGG RCEAGRYFLG TPQAGREPWW GSRAALPLTK ASPESREAYE NSMPHIASVH RIHGRGHWDE DSVVSSPDPG SASESGDRYR TEQYQSSPHE PSKIETLIRA TQQMIKEEEN RLQLRKAPSD QLASINGAGK KHSLCFANYQ QPPPTGEVCH GSALANTSPC DHIQQREGKM LSPHENDYDN SPTALSRISS PNSDRISKSS LILAKDYLHS DISPHQTAGD HPTVSPNCFG SHRQYFDKHA YTLTGYALEH LYDSETIRNY SLGCNGSHFD VTSHLRMQPD PAQGHKGTSV IITNGS
Research Areas
Citations (0)

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Background

SIM1 and SIM2 genes are Drosophila single-minded (sim)gene homologs. SIM1 transcript was detected only in fetal kidneyout of various adult and fetal tissues tested. Since the sim geneplays an important role in Drosophila development and has peaklevels of expression during the period of neurogenesis,it wasproposed that the human SIM gene is a candidate for involvement incertain dysmorphic features (particularly the facial and skullcharacteristics), abnormalities of brain development, and/or mentalretardation of Down syndrome.

References

Ghoussaini, M., et al. Obesity (Silver Spring) 18(8):1670-1675(2010)Tolson, K.P., et al. J. Neurosci. 30(10):3803-3812(2010)Traurig, M., et al. Diabetes 58(7):1682-1689(2009)Gregorio, S.P., et al. Psychiatry Res 165 (1-2), 1-9 (2009) :Hung, C.C., et al. Int J Obes (Lond) 31(3):429-434(2007)

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$ 80.00
Cat# BP12960a
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