|Other Names||Gastric intrinsic factor, Intrinsic factor, IF, INF, GIF, IFMH|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.|
|Tissue Location||Gastric mucosa.|
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Provided below are standard protocols that you may find useful for product applications.
This gene is a member of the cobalamin transport proteinfamily. It encodes a glycoprotein secreted by parietal cells of thegastric mucosa and is required for adequate absorption of vitaminB12. Vitamin B12 is necessary for erythrocyte maturation andmutations in this gene may lead to congenital pernicious anemia.
Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)Andersen, C.B., et al. Nature 464(7287):445-448(2010)Ament, A.E., et al. Br. J. Haematol. 144(4):622-624(2009)Remacha, A.F., et al. Ann. Hematol. 87(7):599-600(2008)Mathews, F.S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(44):17311-17316(2007)
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