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GIF Antibody (Center) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession P27352
Clone Names 100324214
Peptide ID 100324214
Additional Information
Gene ID 2694
Other Names Gastric intrinsic factor, Intrinsic factor, IF, INF, GIF, IFMH
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name GIF
Synonyms IFMH
Function Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the GIF-cobalamin complex is internalized via receptor-mediated endocytosis.
Cellular Location Secreted.
Tissue Location Gastric mucosa.
Research Areas
Citations (0)

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Background

This gene is a member of the cobalamin transport proteinfamily. It encodes a glycoprotein secreted by parietal cells of thegastric mucosa and is required for adequate absorption of vitaminB12. Vitamin B12 is necessary for erythrocyte maturation andmutations in this gene may lead to congenital pernicious anemia.

References

Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)Andersen, C.B., et al. Nature 464(7287):445-448(2010)Ament, A.E., et al. Br. J. Haematol. 144(4):622-624(2009)Remacha, A.F., et al. Ann. Hematol. 87(7):599-600(2008)Mathews, F.S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(44):17311-17316(2007)

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$ 80.00
Cat# BP12975c
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