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GIF Antibody (Center) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | P27352 |
|---|---|
| Clone Names | 100324214 |
| Gene ID | 2694 |
|---|---|
| Other Names | Gastric intrinsic factor, Intrinsic factor, IF, INF, GIF, IFMH |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | CBLIF (HGNC:4268) |
|---|---|
| Function | Promotes absorption of the essential vitamin cobalamin (Cbl) in the ileum. After interaction with CUBN, the CBLIF-cobalamin complex is internalized via receptor-mediated endocytosis. |
| Cellular Location | Secreted. |
| Tissue Location | Gastric mucosa. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
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Provided below are standard protocols that you may find useful for product applications.
Background
This gene is a member of the cobalamin transport proteinfamily. It encodes a glycoprotein secreted by parietal cells of thegastric mucosa and is required for adequate absorption of vitaminB12. Vitamin B12 is necessary for erythrocyte maturation andmutations in this gene may lead to congenital pernicious anemia.
References
Levine, A.J., et al. Cancer Epidemiol. Biomarkers Prev. 19(7):1812-1821(2010)Andersen, C.B., et al. Nature 464(7287):445-448(2010)Ament, A.E., et al. Br. J. Haematol. 144(4):622-624(2009)Remacha, A.F., et al. Ann. Hematol. 87(7):599-600(2008)Mathews, F.S., et al. Proc. Natl. Acad. Sci. U.S.A. 104(44):17311-17316(2007)
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