|Other Names||Consortin, CNST, C1orf71|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Required for targeting of connexins to the plasma membrane.|
|Cellular Location||Cell membrane; Single-pass membrane protein. Golgi apparatus, trans-Golgi network membrane; Single-pass membrane protein. Cytoplasmic vesicle, secretory vesicle. Note=Located predominantly in the trans-Golgi network. Probably trafficks between the trans- Golgi network and the cell membrane via the secretory pathway|
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Provided below are standard protocols that you may find useful for product applications.
Targeting of numerous transmembrane proteins to the cellsurface is thought to depend on their recognition by cargoreceptors that interact with the adaptor machinery for anterogradetraffic at the distal end of the Golgi complex. Consortin (CNST) isan integral membrane protein that acts as a binding partner ofconnexins, the building blocks of gap junctions, and acts as atrans-Golgi network (TGN) receptor involved in connexin targetingto the plasma membrane and recycling from the cell surface (delCastillo et al., 2010 [PubMed 19864490]).
del Castillo, F.J., et al. Hum. Mol. Genet. 19(2):262-275(2010)Simpson, J.C., et al. EMBO Rep. 1(3):287-292(2000)
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