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UBE2J2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
| Primary Accession | Q8N2K1 |
|---|---|
| Clone Names | 101008234 |
| Gene ID | 118424 |
|---|---|
| Other Names | Ubiquitin-conjugating enzyme E2 J2, Non-canonical ubiquitin-conjugating enzyme 2, NCUBE-2, UBE2J2, NCUBE2 |
| Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
| Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
| Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
| Name | UBE2J2 |
|---|---|
| Synonyms | NCUBE2 |
| Function | Catalyzes the covalent attachment of ubiquitin to other proteins. Seems to function in the selective degradation of misfolded membrane proteins from the endoplasmic reticulum (ERAD) (By similarity). In cooperation with the GATOR2 complex, catalyzes 'Lys-6'- linked ubiquitination of NPRL2 (PubMed:36528027). |
| Cellular Location | Endoplasmic reticulum membrane {ECO:0000250|UniProtKB:Q9Y385}; Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q9Y385} |
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Provided below are standard protocols that you may find useful for product applications.
Background
The modification of proteins with ubiquitin is animportant cellular mechanism for targeting abnormal or short-livedproteins for degradation. Ubiquitination involves at least threeclasses of enzymes: ubiquitin-activating enzymes, or E1s,ubiquitin-conjugating enzymes, or E2s, and ubiquitin-proteinligases, or E3s. This gene encodes a member of the E2ubiquitin-conjugating enzyme family. This enzyme is located in themembrane of the endoplasmic reticulum. Multiple alternativelyspliced transcript variants have been found for this gene, but thefull-length nature of some variants has not been defined. [providedby RefSeq].
References
David, Y., et al. J. Biol. Chem. 285(12):8595-8604(2010)Oh, J.H., et al. Mamm. Genome 16(12):942-954(2005)Tiwari, S., et al. J. Biol. Chem. 276(19):16193-16200(2001)Chen, P., et al. Cell 74(2):357-369(1993)
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