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BCL2A1 (A1) Antibody (BH3 Domain Specific) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q16548
Clone Names 2041501
Peptide ID 2041501
Additional Information
Gene ID 597
Other Names Bcl-2-related protein A1, Bcl-2-like protein 5, Bcl2-L-5, Hemopoietic-specific early response protein, Protein BFL-1, Protein GRS, BCL2A1, BCL2L5, BFL1, GRS, HBPA1
Target/Specificity The synthetic peptide sequence used to generate the antibody AP1300a was selected from the region of human A1 BH3 Domain. A 10 to 100 fold molar excess to antibody is recommended. Precise conditions should be optimized for a particular assay.
Format The synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml deionized water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name BCL2A1
Synonyms BCL2L5, BFL1, GRS, HBPA1
Function Retards apoptosis induced by IL-3 deprivation. May function in the response of hemopoietic cells to external signals and in maintaining endothelial survival during infection (By similarity).
Cellular Location Cytoplasm.
Tissue Location Seems to be restricted to the hematopoietic compartment. Expressed in peripheral blood, spleen, and bone marrow, at moderate levels in lung, small intestine and testis, at a minimal levels in other tissues. Also found in vascular smooth muscle cells and hematopoietic malignancies
Research Areas
Citations (0)

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Background

Bcl-2 related Protein A1 is a member of the BCL-2 protein family. The proteins of this family form hetero- or homodimers and act as anti- and pro-apoptotic regulators that are involved in a wide variety of cellular activities such as embryonic development, homeostasis and tumorigenesis. The protein encoded by this gene is able to reduce the release of pro-apoptotic cytochrome c from mitochondria and block caspase activation. This gene is a direct transcription target of NF-kappa B in response to inflammatory mediators, and has been shown to be up-regulated by different extracellular signals, such as granulocyte-macrophage colony-stimulating factor (GM-CSF), CD40, phorbol ester and inflammatory cytokine TNF and IL-1, which suggests a cytoprotective function that is essential for lymphocyte activation as well as cell survival.

References

Akatsuka, Y., et al., J. Exp. Med. 197(11):1489-1500 (2003).Edelstein, L.C., et al., Mol. Cell. Biol. 23(8):2749-2761 (2003).Werner, A.B., et al., J. Biol. Chem. 277(25):22781-22788 (2002).Akari, H., et al., J. Exp. Med. 194(9):1299-1311 (2001).Harrington, J.J., et al., Nat. Biotechnol. 19(5):440-445 (2001).

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$ 80.00
Cat# BP1300a
Size:
Quantity:
(40 western blots)
Availability: In Stock
Bulk Size
Seasonal Special on Bulk Order
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