|Other Names||Nitrilase homolog 1, 35--, NIT1|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Plays a role in cell growth and apoptosis: loss of expression promotes cell growth and resistance to DNA damage stress. Has tumor suppressor properties that enhances the apoptotic responsiveness in cancer cells; this effect is additive to the tumor suppressor activity of FHIT. It is also a negative regulator of primary T-cells. Has apparently no omega-amidase activity such as NIT2 (By similarity).|
|Cellular Location||Cytoplasm. Mitochondrion.|
|Tissue Location||Detected in heart, brain, placenta, liver, skeletal muscle, kidney and pancreas|
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Provided below are standard protocols that you may find useful for product applications.
This gene encodes a member of the nitrilase protein familywith homology to bacterial and plant nitrilases, enzymes thatcleave nitriles and organic amides to the corresponding carboxylicacids plus ammonia. Multiple transcript variants encoding differentisoforms have been found for this gene.
Semba, S., et al. J. Biol. Chem. 281(38):28244-28253(2006)Wang, A.G., et al. Biochem. Biophys. Res. Commun. 345(3):1022-1032(2006)Pekarsky, Y., et al. Proc. Natl. Acad. Sci. U.S.A. 95(15):8744-8749(1998)
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