|Other Names||Phosphatidylserine synthase 2, PSS-2, PtdSer synthase 2, Serine-exchange enzyme II, PTDSS2, PSS2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) or phosphatidylcholine (PC) is replaced by L-serine. PTDSS2 is specific for phosphatatidylethanolamine and does not act on phosphatidylcholine.|
|Cellular Location||Endoplasmic reticulum membrane; Multi-pass membrane protein Note=Highly enriched in the mitochondria-associated membrane (MAM).|
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Provided below are standard protocols that you may find useful for product applications.
Phosphatidylserine (PS) accounts for 5 to 10% of cellmembrane phospholipids. In addition to its role as a structuralcomponent, PS is involved in cell signaling, blood coagulation, andapoptosis. PS is synthesized by a calcium-dependent base-exchangereaction catalyzed by PS synthases (EC 18.104.22.168), like PTDSS2, thatexchange L-serine for the polar head group of phosphatidylcholine(PC) or phosphatidylethanolamine (PE) (Sturbois-Balcerzak et al.,2001 [PubMed 11084049]).
Tomohiro, S., et al. Biochem. J. 418(2):421-429(2009)Olsen, J.V., et al. Cell 127(3):635-648(2006)Olsen, J.V., et al. Cell 127(3):635-648(2006)Grandmaison, P.A., et al. Biochim. Biophys. Acta 1636(1):1-11(2004)Sturbois-Balcerzak, B., et al. J. Biol. Chem. 276(11):8205-8212(2001)
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