|Other Names||Chorionic somatomammotropin hormone-like 1, Chorionic somatomammotropin-like, Lactogen-like, CSHL1, CSHP1, CSL|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||May be a novel gestational hormone required to compensate for absence of other members of the GH/CS cluster during gestation.|
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The protein encoded by this gene is a member of thesomatotropin/prolactin family of hormones which play an importantrole in growth control. The gene, along with four other relatedgenes, is located at the growth hormone locus on chromosome 17where they are interspersed in the same transcriptionalorientation; an arrangement which is thought to have evolved by aseries of gene duplications. Although the five genes share aremarkably high degree of sequence identity, they are expressedselectively in different tissues. This particular family member isexpressed in placental villi, although it was originally thought tobe a pseudogene. In fact, alternative splicing suggests that themajority of the transcripts would be unable to express a secretedprotein. Alternatively spliced transcript variants encodingdifferent isoforms have been identified.
Bailey, S.D., et al. Diabetes Care (2010) In press :Talmud, P.J., et al. Am. J. Hum. Genet. 85(5):628-642(2009)Misra-Press, A., et al. J. Biol. Chem. 269(37):23220-23229(1994)MacLeod, J.N., et al. J. Biol. Chem. 267(20):14219-14226(1992)Vnencak-Jones, C.L., et al. Science 250(4988):1745-1748(1990)
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