|Other Names||Progesterone receptor, PR, Nuclear receptor subfamily 3 group C member 3, PGR, NR3C3|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Progesterone receptor isoform B (PRB) is involved activation of c-SRC/MAPK signaling on hormone stimulation. Isoform 4: Increases mitochondrial membrane potential and cellular respiration upon stimulation by progesterone.|
|Cellular Location||Nucleus. Cytoplasm. Note=Nucleoplasmic shuttling is both homone- and cell cycle-dependent. On hormone stimulation, retained in the cytoplasm in the G(1) and G(2)/M phases Isoform 4: Mitochondrion outer membrane|
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This gene encodes a member of the steroid receptorsuperfamily. The encoded protein mediates the physiological effectsof progesterone, which plays a central role in reproductive eventsassociated with the establishment and maintenance of pregnancy.This gene uses two distinct promotors and translation start sitesin the first exon to produce two isoforms, A and B. The twoisoforms are identical except for the additional 165 amino acidsfound in the N-terminus of isoform B and mediate their own responsegenes and physiologic effects with little overlap. The location oftranscription initiation for isoform A has not been clearlydetermined.
Geradts, J., et al. Cancer Invest. 28(9):969-977(2010)Tang, P., et al. Cancer Invest. 28(9):978-982(2010)Van Belle, V., et al. J. Clin. Oncol. 28(27):4129-4134(2010)Taylor, K.C., et al. Horm Res Paediatr (2010) In press :Near, A.M., et al. Fertil. Steril. (2010) In press :
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