ATAD2 Antibody (N-term) Blocking peptide
Synthetic peptide
- SPECIFICATION
- CITATIONS
- PROTOCOLS
- BACKGROUND
Primary Accession | Q6PL18 |
---|---|
Clone Names | 110111072 |
Gene ID | 29028 |
---|---|
Other Names | ATPase family AAA domain-containing protein 2, AAA nuclear coregulator cancer-associated protein, ANCCA, ATAD2 |
Format | Peptides are lyophilized in a solid powder format. Peptides can be reconstituted in solution using the appropriate buffer as needed. |
Storage | Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C. |
Precautions | This product is for research use only. Not for use in diagnostic or therapeutic procedures. |
Name | ATAD2 |
---|---|
Function | May be a transcriptional coactivator of the nuclear receptor ESR1 required to induce the expression of a subset of estradiol target genes, such as CCND1, MYC and E2F1. May play a role in the recruitment or occupancy of CREBBP at some ESR1 target gene promoters. May be required for histone hyperacetylation. Involved in the estrogen-induced cell proliferation and cell cycle progression of breast cancer cells. |
Cellular Location | Nucleus |
Tissue Location | Highly expressed in estrogen receptor positive breast tumors and in osteosarcoma tumors. |
Thousands of laboratories across the world have published research that depended on the performance of antibodies from Abcepta to advance their research. Check out links to articles that cite our products in major peer-reviewed journals, organized by research category.
info@abcepta.com, and receive a free "I Love Antibodies" mug.
Provided below are standard protocols that you may find useful for product applications.
Background
A large family of ATPases has been described, whose keyfeature is that they share a conserved region of about 220 aminoacids that contains an ATP-binding site. The proteins that belongto this family either contain one or two AAA (ATPases Associatedwith diverse cellular Activities) domains. AAA family proteinsoften perform chaperone-like functions that assist in the assembly,operation, or disassembly of protein complexes. The protein encodedby this gene contains two AAA domains, as well as a bromodomain.
References
Revenko, A.S., et al. Mol. Cell. Biol. 30(22):5260-5272(2010)Ciro, M., et al. Cancer Res. 69(21):8491-8498(2009)Zou, J.X., et al. Cancer Res. 69(8):3339-3346(2009)Zou, J.X., et al. Proc. Natl. Acad. Sci. U.S.A. 104(46):18067-18072(2007)Olsen, J.V., et al. Cell 127(3):635-648(2006)
If you have used an Abcepta product and would like to share how it has performed, please click on the "Submit Review" button and provide the requested information. Our staff will examine and post your review and contact you if needed.
If you have any additional inquiries please email technical services at tech@abcepta.com.