|Other Names||Potassium voltage-gated channel subfamily V member 2, Voltage-gated potassium channel subunit Kv82, KCNV2|
|Format||Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.|
|Storage||Maintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.|
|Precautions||This product is for research use only. Not for use in diagnostic or therapeutic procedures.|
|Function||Potassium channel subunit. Modulates channel activity by shifting the threshold and the half-maximal activation to more negative values.|
|Cellular Location||Cell membrane; Multi-pass membrane protein. Note=Has to be associated with KCNB1 or possibly another partner to get inserted in the plasma membrane. Remains intracellular in the absence of KCNB1|
|Tissue Location||Detected in lung, liver, kidney, pancreas, spleen, thymus, prostate, testis, ovary and colon|
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Voltage-gated potassium (Kv) channels represent the mostcomplex class of voltage-gated ion channels from both functionaland structural standpoints. Their diverse functions includeregulating neurotransmitter release, heart rate, insulin secretion,neuronal excitability, epithelial electrolyte transport, smoothmuscle contraction, and cell volume. This gene encodes a member ofthe potassium voltage-gated channel subfamily V. This member isidentified as a 'silent subunit', and it does not formhomomultimers, but forms heteromultimers with several othersubfamily members. Through obligatory heteromerization, it exerts afunction-altering effect on other potassium channel subunits. Thisprotein is strongly expressed in pancreas and has a weakerexpression in several other tissues.
Robson, A.G., et al. Retina (Philadelphia, Pa.) 30(1):51-62(2010)Ben Salah, S., et al. Am. J. Ophthalmol. 145(6):1099-1106(2008)Wissinger, B., et al. Invest. Ophthalmol. Vis. Sci. 49(2):751-757(2008)Thiagalingam, S., et al. Ophthalmic Genet. 28(3):135-142(2007)Balijepalli, R.C., et al. Channels (Austin) 1(4):263-272(2007)
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