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KAT2A Antibody (C-term) Blocking peptide

Synthetic peptide

     
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Product Information
Primary Accession Q92830
Clone Names 110111060
Peptide ID 110111060
Additional Information
Gene ID 2648
Other Names Histone acetyltransferase KAT2A, General control of amino acid synthesis protein 5-like 2, Histone acetyltransferase GCN5, HsGCN5, Lysine acetyltransferase 2A, STAF97, KAT2A, GCN5, GCN5L2, HGCN5
Format Synthetic peptide was lyophilized with 100% acetonitrile and is supplied as a powder. Reconstitute with 0.1 ml DI water for a final concentration of 1 mg/ml.
StorageMaintain refrigerated at 2-8°C for up to 6 months. For long term storage store at -20°C.
PrecautionsThis product is for research use only. Not for use in diagnostic or therapeutic procedures.
Protein Information
Name KAT2A (HGNC:4201)
Function Protein lysine acyltransferase that can act both as a acetyltransferase and succinyltransferase, depending on the context (PubMed:29211711). Acts as a histone lysine succinyltransferase: catalyzes succinylation of histone H3 on 'Lys-79' (H3K79succ), with a maximum frequency around the transcription start sites of genes (PubMed:29211711). Succinylation of histones gives a specific tag for epigenetic transcription activation (PubMed:29211711). Association with the 2-oxoglutarate dehydrogenase complex, which provides succinyl-CoA, is required for histone succinylation (PubMed:29211711). In different complexes, functions either as an acetyltransferase (HAT) or as a succinyltransferase: in the SAGA and ATAC complexes, acts as a histone acetyltransferase (PubMed:17301242, PubMed:19103755, PubMed:29211711). Has significant histone acetyltransferase activity with core histones, but not with nucleosome core particles (PubMed:17301242, PubMed:19103755). Acetylation of histones gives a specific tag for epigenetic transcription activation (PubMed:17301242, PubMed:19103755, PubMed:29211711). Involved in long-term memory consolidation and synaptic plasticity: acts by promoting expression of a hippocampal gene expression network linked to neuroactive receptor signaling (By similarity). Acts as a positive regulator of T-cell activation: upon TCR stimulation, recruited to the IL2 promoter following interaction with NFATC2 and catalyzes acetylation of histone H3 at Lys-9 (H3K9ac), leading to promote IL2 expression (By similarity). Also acetylates non-histone proteins, such as CEBPB, PLK4 and TBX5 (PubMed:17301242, PubMed:29174768, PubMed:27796307). Involved in heart and limb development by mediating acetylation of TBX5, acetylation regulating nucleocytoplasmic shuttling of TBX5 (PubMed:29174768). Acts as a negative regulator of centrosome amplification by mediating acetylation of PLK4 (PubMed:27796307).
Cellular Location Nucleus Chromosome. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Mainly localizes to the nucleus. Also localizes to centrosomes in late G1 and around the G1/S transition, coinciding with the onset of centriole formation
Tissue Location Expressed in all tissues tested, with most abundant expression in ovary
Research Areas
Citations (0)

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Background

KAT2A, or GCN5, is a histone acetyltransferase (HAT) thatfunctions primarily as a transcriptional activator. It alsofunctions as a repressor of NF-kappa-B (see MIM 164011) bypromoting ubiquitination of the NF-kappa-B subunit RELA (MIM164014) in a HAT-independent manner (Mao et al., 2009 [PubMed19339690]).

References

Terreni, M., et al. Retrovirology 7, 18 (2010) :Atanassov, B.S., et al. Mol. Cell 35(3):352-364(2009)Kelly, T.J., et al. J. Biol. Chem. 284(30):19945-19952(2009)Mao, X., et al. Genes Dev. 23(7):849-861(2009)Paolinelli, R., et al. Nat. Struct. Mol. Biol. 16(4):412-420(2009)

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$ 80.00
Cat# BP13089b
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